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Am J Epidemiol 1979, 110: 28190

Weeks to months, depending on severity and route of supplementation

Pilot human studies describe measurable alterations in adipose-related metabolic markers without direct stimulation of systemic growth hormone levels

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Neuropathy scores improved in seven patients, mostly in patients with immune-mediated neuropathy, but remained unchanged or worsened in the remaining five patients (two patients dropped out due to adverse events that were considered unrelated to B12)